Ramos was taken off in the 43rd minute of Spain’s 6-0 victory over Germany in the UEFA Nations League, while Varane was substituted at half-time against Sweden on Tuesday night.
To add to Zinedine Zidane’s headache, Madrid are also missing their third-choice centre back Eder Militao, after he tested positive for coronavirus on November 2.
Ramos became the most capped European player ever on Saturday by featuring in his 178th international, but failed to complete the game.
Ramos was seen gesturing to the back of his right thigh as he limped off following the half-time break.
Thankfully, Spain were already 3-0 up after Alvaro Morata, Ferran Torres and Rodri found the net.
A statement from the Spanish football federation admitted that the Ramos was suffering from ‘severe discomfort in his right hamstring’, while manager Luis Enrique played down his injury, saying it wasn’t ‘too serious’.
‘We don’t believe the injuries are too serious or important,’ Luis Enrique said at his post-match press conference.
‘But it’s still an unpleasant moment for everyone. I feel bad for their clubs but this is how it is,’ he added.
It is believed Ramos will undergo further tests on Wednesday and an assessment of his injury will be made following the results.
Meanwhile, Varane – who came off during France’s 4-2 victory over Sweden in Paris – has hamstring problems of his own.
France national team coach Didier Deschamps confirmed his injury, saying: ‘[Lucas] Hernandez and Varane came off because they had little problems.’
Zidane will be hoping both injuries are minor and each of them will be fit on their return to Real Madrid as the Spanish champions have an important run of games coming up.
His side are set to face second-placed Villarreal on Saturday, following the international break.